Name | 3,5-dihydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one |
Synonyms | Rhamnocitrin hydroxygenkwanin hydroxyl genkwanin 7-O-Methylluteolin 3'-hydroxygenkwanin Luteolin 7-methylether 3',4',5-Trihydroxy-7-methoxyflavone 3,5-Dihydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one 3,5-dihydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one 2-(3,4-Dihydroxyphenyl)-5-hydroxy-7-methoxy-4H-1-benzopyran-4-one 2-(3,4-Dihydroxyphenyl)-7-methoxy-5-hydroxy-4H-1-benzopyran-4-one 4H-1-Benzopyran-4-one, 3,5-dihydroxy-2-(4-hydroxyphenyl)-7-methoxy- |
CAS | 20243-59-8 569-92-6 |
InChI | InChI=1/C16H12O6/c1-21-10-6-11(18)13-12(7-10)22-16(15(20)14(13)19)8-2-4-9(17)5-3-8/h2-7,17-18,20H,1H3 |
Molecular Formula | C16H12O6 |
Molar Mass | 300.26 |
Density | 1.512±0.06 g/cm3(Predicted) |
Melting Point | 258-260 °C |
Boling Point | 602.7±55.0 °C(Predicted) |
Flash Point | 218.4°C |
Solubility | DMSO: 60 mg/mL (199.82 mM) |
Vapor Presure | 6.45E-14mmHg at 25°C |
Appearance | Yellow powder |
pKa | 6.33±0.40(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.709 |
MDL | MFCD11046350 |
Physical and Chemical Properties | Yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Daphne genkwa. |
In vitro study | Hydroxygenkwanin (7-O-Methylluteolin) inhibits C6 glioma cell proliferation in a dose dependent manner. Hydroxygenkwanin induces the cell cycle arrest by flow cytometry and inhibits colony formation ability and cell movement. Hydroxygenkwanin induces cell cycle arrest through p21 activation and causes intrinsic cell apoptosis pathway. |